What should I do about my puppy?

Last night I brought home a 6 week old Rottweilier/Boxer puppy. This puppy has been sperated from his mom since he was 4 weeks old. When I brought him home last night he was running around scratching our walls, our doors, our furniature while he was crying - extremely loud! I would pick him up and hold him to calm him down and nothing worked even when I got him some what calmed down he seemed like he was hyperventilating with how fast he was breathing. He only stayed somewhat calmed down for maybe 10 minutes out of the 6 hours he was at my place. He would even continue to cry when I would play with him. I don't know what to do. What are some suggestions?